Browsing Brock Theses by Subject "Muscles"
Now showing items 1-7 of 7
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The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise
(Brock University, 2006-06-29)Pyruvate dehydrogenase (PDH) is an important regulator of carbohydrate oxidation during exercise and its activity can be down-regulated by an increase in dietary fat. The purpose of this study was to determine the acute ... -
Adaptations of skeletal muscle pyruvate dehydrogenase kinase in response to food-restriction in mitochondrial subpopulations
(Brock University, 2007-06-09)University, 2006 Dr. Sandra J. Peters Pyruvate dehydrogenase (PDH) catalyses the decarboxylation of pyruvate, to form acetyl-CoA. PDH activity is down-regulated by intrinsic PDH kinases (predominantly PDK2 and PDK4 ... -
The capillary supply of human skeletal muscle in health and disease
(Brock University, 2006-06-04)BACKGROUND: Capillaries function to provide a surface area for nutrient and waste exchange with cells. The capillary supply of skeletal muscle is highly organized, and therefore, represents an excellent choice to study ... -
The effect of elevated muscle fluid volume on indices of muscle damage following an acute bout of eccentric exercise
(Brock University, 2008-06-15)The primary purpose of the current investigation was to develop an elevated muscle fluid level using a human in-vivo model. The secondary purpose was to determine if an increased muscle fluid content could alter the acute ... -
The effect of extracellular osmolality on cell volume and resting skeletal muscle metabolism
(Brock University, 2006-06-29)The purpose of the current investigation was to establish an in-l'itro skeletal muscle model to study acute alterations in resting skeletal muscle cell volume. Isolated. whole muscle (SOL and EDL) was dissected from Long ... -
The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
(Brock University, 2006-06-04)This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ... -
The influence of skeletal muscle cell volume on the regulation of carbohydrate uptake and muscle metabolism
(Brock University, 2007-06-01)This study investigated the regulation of carbohydrate metabolism and glucose uptake through changes in skeletal muscle cell volume. Using an established invitro isolated whole muscle model, soleus (SOL) and extensor ...